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The 12 hallmarks of aging

The body is a delicate and beautiful ecosystem of processes and chemicals keeping us running. Explore the 12 Hallmarks of cellular processes that impact our natural aging.

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THE 12 HALLMARKS OF AGING

Mitochondrial Dysfunction

Mitochondrial Dysfunction

Mitochondria are the cell's powerhouses, producing ATP through oxidative phosphorylation. However, this process also generates...

Mitochondrial Dysfunction

Mitochondria are the cell's powerhouses, producing ATP through oxidative phosphorylation. However, this process also generates...

Deregulated Nutrient-Sensing (Metabolic Disorders)

Deregulated Nutrient-Sensing (Metabolic Disorders)

Nutrient-sensing pathways like insulin/IGF-1, mTOR, and sirtuins play crucial roles in metabolism and longevity. With...

Deregulated Nutrient-Sensing (Metabolic Disorders)

Nutrient-sensing pathways like insulin/IGF-1, mTOR, and sirtuins play crucial roles in metabolism and longevity. With...

Disabled Macroautophagy

Disabled Macroautophagy

Autophagy is the process by which cells break down and recycle damaged components. It's crucial...

Disabled Macroautophagy

Autophagy is the process by which cells break down and recycle damaged components. It's crucial...

Loss of Proteostasis

Loss of Proteostasis

Proteostasis is the balance between protein production, folding, and degradation. As we age, this balance...

Loss of Proteostasis

Proteostasis is the balance between protein production, folding, and degradation. As we age, this balance...

Epigenetic Alterations

Epigenetic Alterations

Epigenetic changes involve modifications to DNA or histones that affect gene expression without altering the...

Epigenetic Alterations

Epigenetic changes involve modifications to DNA or histones that affect gene expression without altering the...

Telomere Attrition

Telomere Attrition

Telomeres are protective structures at the ends of our chromosomes, similar to the plastic caps...

Telomere Attrition

Telomeres are protective structures at the ends of our chromosomes, similar to the plastic caps...

Genomic Instability

Genomic Instability

Over time, DNA accumulates damage from various sources like radiation, chemical exposure, and replication errors....

Genomic Instability

Over time, DNA accumulates damage from various sources like radiation, chemical exposure, and replication errors....

Dysbiosis - Microbiome

Dysbiosis - Microbiome

Microbiome dysbiosis refers to an imbalance or disruption in the composition of the trillions of...

Dysbiosis - Microbiome

Microbiome dysbiosis refers to an imbalance or disruption in the composition of the trillions of...

Chronic Inflammation

Chronic Inflammation

Also known as "inflammaging," this hallmark involves a low-grade, chronic inflammatory state that develops with...

Chronic Inflammation

Also known as "inflammaging," this hallmark involves a low-grade, chronic inflammatory state that develops with...

Altered Intercellular Communication

Altered Intercellular Communication

Aging affects how cells communicate with each other.   Cellular communication refers to the process...

Altered Intercellular Communication

Aging affects how cells communicate with each other.   Cellular communication refers to the process...

Stem Cell Exhaustion

Stem Cell Exhaustion

Stem cells are crucial for tissue repair and regeneration. However, as we age, their number...

Stem Cell Exhaustion

Stem cells are crucial for tissue repair and regeneration. However, as we age, their number...

Cellular Senescence

Cellular Senescence

When cells experience stress or damage, they can enter a state of senescence—they stop dividing...

Cellular Senescence

When cells experience stress or damage, they can enter a state of senescence—they stop dividing...