The 12 hallmarks of aging
The body is a delicate and beautiful ecosystem of processes and chemicals keeping us running. Explore the 12 Hallmarks of cellular processes that impact our natural aging.
THE 12 HALLMARKS OF AGING
Mitochondrial Dysfunction
Mitochondria are the cell's powerhouses, producing ATP through oxidative phosphorylation. However, this process also generates...
Mitochondrial Dysfunction
Mitochondria are the cell's powerhouses, producing ATP through oxidative phosphorylation. However, this process also generates...
Deregulated Nutrient-Sensing (Metabolic Disorders)
Nutrient-sensing pathways like insulin/IGF-1, mTOR, and sirtuins play crucial roles in metabolism and longevity. With...
Deregulated Nutrient-Sensing (Metabolic Disorders)
Nutrient-sensing pathways like insulin/IGF-1, mTOR, and sirtuins play crucial roles in metabolism and longevity. With...
Disabled Macroautophagy
Autophagy is the process by which cells break down and recycle damaged components. It's crucial...
Disabled Macroautophagy
Autophagy is the process by which cells break down and recycle damaged components. It's crucial...
Loss of Proteostasis
Proteostasis is the balance between protein production, folding, and degradation. As we age, this balance...
Loss of Proteostasis
Proteostasis is the balance between protein production, folding, and degradation. As we age, this balance...
Epigenetic Alterations
Epigenetic changes involve modifications to DNA or histones that affect gene expression without altering the...
Epigenetic Alterations
Epigenetic changes involve modifications to DNA or histones that affect gene expression without altering the...
Telomere Attrition
Telomeres are protective structures at the ends of our chromosomes, similar to the plastic caps...
Telomere Attrition
Telomeres are protective structures at the ends of our chromosomes, similar to the plastic caps...
Genomic Instability
Over time, DNA accumulates damage from various sources like radiation, chemical exposure, and replication errors....
Genomic Instability
Over time, DNA accumulates damage from various sources like radiation, chemical exposure, and replication errors....
Dysbiosis - Microbiome
Microbiome dysbiosis refers to an imbalance or disruption in the composition of the trillions of...
Dysbiosis - Microbiome
Microbiome dysbiosis refers to an imbalance or disruption in the composition of the trillions of...
Chronic Inflammation
Also known as "inflammaging," this hallmark involves a low-grade, chronic inflammatory state that develops with...
Chronic Inflammation
Also known as "inflammaging," this hallmark involves a low-grade, chronic inflammatory state that develops with...
Altered Intercellular Communication
Aging affects how cells communicate with each other. Cellular communication refers to the process...
Altered Intercellular Communication
Aging affects how cells communicate with each other. Cellular communication refers to the process...
Stem Cell Exhaustion
Stem cells are crucial for tissue repair and regeneration. However, as we age, their number...
Stem Cell Exhaustion
Stem cells are crucial for tissue repair and regeneration. However, as we age, their number...
Cellular Senescence
When cells experience stress or damage, they can enter a state of senescence—they stop dividing...
Cellular Senescence
When cells experience stress or damage, they can enter a state of senescence—they stop dividing...