Nutrient-sensing pathways like insulin/IGF-1, mTOR, and sirtuins play crucial roles in metabolism and longevity. With age, these pathways become less sensitive, leading to metabolic disorders. For example, insulin resistance can lead to type 2 diabetes. Conversely, reducing nutrient signaling through caloric restriction or drugs like rapamycin (mTOR inhibitor) can extend lifespan in various species.

Essential Longevity ingredients that interact with deregulated nutrient sensing (metabolic disorders):

• Lion's Mane Mushroom
• Chaga Mushroom
• Agaricus Mushroom
• Quercetin
• Glycine
• Taurine
• Vitamin D3
• Vitamin C
• Vitamin B12
• Nicotinamide
• Beta-Glucans (1,3 1,6)
• Phosphatidylcholine
• Cinnamon
• MCT Oil
• Choline