Magnesium Glycinate

Our Magnesium is derived from magnesium glycinate, the most absorbable form of magnesium and easiest on digestion. Our magnesium combines the mineral magnesium with the amino acid glycine.

Magnesium itself is an essential mineral that plays numerous important roles in the body, such as supporting muscle and nerve function, maintaining heart rhythm, and contributing to bone strength.

When magnesium is combined with glycine, it is believed to enhance the absorption and bioavailability of magnesium in the body.

Benefits

Heart health: Magnesium is involved in maintaining a healthy heart rhythm and blood pressure regulation. Adequate magnesium levels may help reduce the risk of cardiovascular diseases, which can impact longevity.

Bone health: Magnesium is essential for maintaining strong bones and teeth. It aids in the absorption and metabolism of calcium, another mineral crucial for bone health. Healthy bones can help prevent fractures and maintain mobility as you age.

Muscle function: Magnesium is necessary for proper muscle function and relaxation. It supports muscle contraction and can help alleviate muscle cramps, spasms, and soreness. Maintaining muscle health is important for maintaining mobility and overall physical well-being.

Sleep quality: Magnesium glycinate, due to its glycine content, may have a calming effect and promote better sleep. Quality sleep is essential for various aspects of health, including cognitive function, immune system regulation, and overall vitality.

Stress reduction: Magnesium is involved in the regulation of stress hormones, such as cortisol. Adequate magnesium levels may help mitigate the negative effects of chronic stress, which can impact longevity by contributing to various health issues.

Antidepressant: In some cases, depression can be caused by a lack of magnesium in nueron channels, as well as a buildup of calcium. This depressive state is then exacerbated by high levels of stress. Magnesium has a twofold benefit in these cases because it reduces cortisol levels and therefore stress, while at the same time repleneshing the magnesium deficiency.

Skin health: Glycine is involved in the synthesis of collagen, which is important for maintaining healthy skin. Some evidence suggests that glycine supplementation may support skin elasticity, wound healing, and overall skin health.

Magnesium effects on 12 Hallmarks of Aging:

Telomere Attrition:

Magnesium affects telomere maintenance by playing a role in DNA replication and repair processes and potentially regulating telomerase activity, while also serving as a key ion in cellular metabolism and DNA/RNA stabilization within the MTR trinity, tightly linked to telomere structure and function regulation.

Epigenetic Alterations:

Magnesium affects gene regulation through histone modifications and DNA methylation, and studies suggest that magnesium deficiency may impact gene expression by altering DNA methylation patterns.

Cellular Scenescence:

Magnesium deficiency leads to accelerated cellular senescence due to its pivotal role in over 300 enzymatic reactions in the body, essential for DNA and protein synthesis, energy production, and maintaining normal cell function.

Inflammation:

Magnesium is involved in many enzymatic reactions in the body that regulate inflammation. It can modulate the production and activity of inflammatory markers, such as cytokines and C-reactive protein (CRP).

Dysregulated Autophagy:

Magnesium affects autophagy-regulating enzymes like PI3K, and its deficiency is linked to impaired autophagy in specific tissues, suggesting a potential role for magnesium in modulating autophagic processes.

Genomic instability:

Magnesium is essential for genomic stability, serving as a cofactor for enzymes in DNA repair and replication processes, thus maintaining DNA integrity and ensuring accurate genetic material duplication.

Mitochondrial Dysfunction:

Magnesium is beneficial for mitochondrial health because it is vital for ATP production, acts as an antioxidant to protect against oxidative stress, and maintains proper calcium balance to prevent mitochondrial dysfunction.

Stem Cell Exhaustion:

Magnesium is involved in cell proliferation and differentiation, which are critical processes for stem cells.

Loss of Proteostasis:

Magnesium plays a role in protein folding and stabilization. It interacts with negatively charged residues in proteins, promoting proper folding and preventing protein misfolding and aggregation.

Deregulated Nutrient Sensing:

Magnesium influences nutrient-sensing pathways, like mTOR and AMPK, responsible for cellular energy status and metabolic homeostasis. It is also associated with insulin resistance.

Intercelluar Communication:

Magnesium's crucial impact on cellular communication lies in its regulation of ion channels, proteins in cell membranes that control the passage of ions like calcium, potassium, and sodium, thereby influencing cell signaling and communication.

Microbiome Dysbiosis:

Conservative dietary magnesium consumption is associated with a microbiota with a higher capacity to harvest energy from the diet.

Sources:

Magnesium Fact sheet for health professionals:

https://ods.od.nih.gov/factsheets/Magnesium-HealthProfessional/

Rapid recovery from major depression using magnesium treatment:

https://pubmed.ncbi.nlm.nih.gov/16542786/

Oral Mg(2+) supplementation reverses age-related neuroendocrine and sleep EEG changes in humans:

https://pubmed.ncbi.nlm.nih.gov/12163983/

Effect of Dietary Magnesium Content on Intestinal Microbiota of Rats:

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7551274/

Multifarious Beneficial Effect of Nonessential Amino Acid, Glycine: A Review: